Sildenafil As The Active Component Of Viagra From Canada

sildenafil in canada

Sildenafil in Canada is a drug of choice number one against erectile dysfunction (ED). Its effectiveness has been demonstrated in numerous randomized clinical trials, controlled vs placebo in double-blind studies on thousands of patients with ED of various etiologies. However, while the first results of studies attesting percentage of success around 85 %, the following clinical practice has shown reduced rates, close to 50%.

Viagra in Canada is highly effective in erectile dysfunction of psychogenic origin and in mild cases – moderate organic in nature, while demonstrating smaller efficacy, though still substantial, in the most severe organic erectile dysfunction.

In diabetic patients, the effectiveness is within 50%. Even in the elderly an improvement is described in performance, presumably through a higher intensity and an extension of erections reflected. After radical prostatectomy, the effectiveness is limited and is completely absent if the intervention has not preserved the innervation of the penis.

As is known, the sexual stimulation causes liberation within the penis of the nitroxide (NO), which in turn, through a series of chemical processes, leads to the final production of cyclic guanosine monophosphate (cGMP). The latter is a substance that promotes intense vasodilation affecting the pudendal artery and its branches spraying the corpora cavernosa through helicine arteries. In this context, cGMP is rapidly metabolized by a specific phosphodiesterase, PDE-5, which turns it into cyclic guanosine monophosphate (GMP) inactive. The cGMP is therefore the true mediator of the intense vessel – expansion in the corpora cavernosa, which allows an erection and maintaining it. Sildenafil works by selectively inhibiting PDE-5. Its action is therefore unrelated to the production of cGMP, which explains why this drug can only enhance a function to be partially present. Who takes the sildenafil in Canada should be remembered that the drug does not replace an erogenous stimulus, nor can it transform into erogenous a stimulus that is not such; it is useless in the subject – jets, for various reasons, have reduced or man – lack of libido; does not have a direct impact on ejaculation or orgasm.

The selective activity of sildenafil on PDE-5, predominantly present in the penile area, explains why the vasodilation induced by this drug is manifested above all in the corpora cavernosa. However, the PDE-5 is present in other body structures (vascular and non-vascular), so the use of sildenafil may result in slight decrease in blood pressure. In healthy volunteers, there was a transient decrease in blood pressure, with no occurrence of orthostatic effects and electrocardiographic changes that are relevant. In patients treated with nitrates, which dilate the vessels, producing NO, the administration of sildenafil in Canada leads to a potentiation of the hypotensive effects with sometimes unpredictable, sometimes lethal.

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